Virus

A virus (Latin, poison) is a submicroscopic particle that can infect the cells of a biological organism. At the most basic level viruses consist of genetic material contained within a protective protein shell, which distinguishes them from other virus-like particles such as prions and viroids. The study of viruses is known as virology, and those who study viruses are called virologists.

Viruses are similar to obligate intracellular parasites as they lack the means for self-reproduction outside a host cell, but unlike parasites, which are living organisms, viruses are not truly alive. They infect a wide variety of organisms, both eukaryotes (such as animals, insects and plants) and prokaryotes (such as bacteria). A virus infecting bacteria is known as a bacteriophage, which is used mainly in its shortened form phage.

It has been argued extensively whether viruses are living organisms. They are considered non-living by the majority of virologists as they do not meet all the criteria of the generally accepted definition of life. Among other factors, viruses do not possess a cell membrane or metabolise on their own. A definitive answer is still elusive due to the fact that some organisms considered to be living exhibit characteristics of both living and non-living particles, as viruses do.

The origins of modern viruses are not entirely clear, and there may not be a single mechanism of origin that can account for all viruses. As viruses do not fossilise well, molecular techniques have been the most useful means of hypothesising how they arose. Research in microfossil identification and molecular biology may yet discern fossil evidence dating to the Archean or Proterozoic eons. Two main hypotheses currently exist:

• Small viruses with only a few genes may be runaway stretches of nucleic acid originating from the genome of a living organism. Their genetic material could have been derived from transferable genetic elements such as plasmids or transposons, which are prone to moving around, exiting, and entering genomes.
• Viruses with larger genomes, such as poxviruses, may have once been small cells which parasitised larger host cells. Over time, genes not required by their parasitic lifestyle would have been lost in a streamlining process known as retrograde evolution – literally reverse evolution. Both the bacteria Rickettsia and Chlamydia are living cells which, like viruses, can only reproduce inside host cells. They lend credence to this hypothesis, as they are likely to have lost genes which enabled them to survive outside a host cell in favour of their parasitic lifestyle.